| 摘要: |
| AMP活化蛋白激酶（AMPK）是细胞内能量感应器，运动可引起肝脏中AMPK活性增加，与细胞内miRNAs、固醇调节元件结合蛋白（SREBPs）、过氧化物酶体增殖物激活受体（PPARs）、核因子κB（NF-κB）等多种细胞因子相互作用，参与细胞内多种生物学功能，包括脂质代谢、炎症过程、线粒体的生物合成、胰岛素抵抗等，改善肥胖、非酒精性脂肪肝和2型糖尿病等代谢性疾病。运动激活肝脏中AMPK信号通路，参与胰岛素抵抗状态下肝脏脂代谢异常的机理调节。 |
| 关键词: 运动 胰岛素抵抗 肝脏 AMPK SREBPs NF-κB |
| DOI： |
|
| 基金项目:广东省哲学社会科学“十三五”规划2017年度学科共建项目（GD17XTY01）；广东第二师范学院博士科研专项经费研究项目（2015ARF14）；广东第二师范学院校级质量工程项目 |
|
| Review of the Studies on Effects of Exercising on AMPK Signaling in the Liver with Insulin Resistance |
| CAO Jiao |
| (Guangdong University of Education) |
| Abstract: |
| AMPK is a cellular energy sensor, and exercise could increase AMPK activity in the liver, which interacts with the intracellular miRNAs, sterol regulatory element binding protein (SREBPs), peroxisomal proliferator activating receptor (PPARs), nuclear factor kappa B (NF-kappa B), and participates in a variety of biological function in the cell, including the biosynthesis of mitochondria, ectopic lipid deposition, angiogenesis, inflammation, insulin resistance and so on. And finally it helps improve metabolic diseases such as obesity, nonalcoholic fatty liver disease and type 2 diabetes. Exercise helps activate AMPK pathway in liver, and then it participates in the mechanism regulation of abnormal lipid metabolism in liver under insulin resistance. |
| Key words: exercise insulin resistance liver AMPK SREBPs NF-κB |
