| 摘要: |
| 磷脂酶A2（PLA2）是一类催化甘油磷脂sn2酯键水解生成多不饱和脂肪酸的酶，与花生四烯酸（AA）一起在阿尔茨海默病（AD）的发病机制中起着重要作用。PLA2和AA与神经元活性有关，抑制PLA2和AA活性可抑制Aβ引起的神经毒性，缓解AD病症。运动对AD的防治已经不言而喻，运动通过抑制PLA2活性来抑制Aβ毒性，缓解AD学习记忆能力的机理仍需进一步研究。 |
| 关键词: 阿尔茨海默病 磷脂酶A2 花生四烯酸 β淀粉样蛋白 运动训练 |
| DOI： |
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| 基金项目: |
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| Functional Mechanisms of Phospholipase A2 in Alzheimer Disease and Sport Exercise Regulation |
| CUI Lili |
| (School of Sport Sciences, Mudanjiang Normal University) |
| Abstract: |
| Phospholipase A2 (PLA2) is a kind of enzyme catalyzing hydrolysis of glycerol phospholipid sn2 ester bonds to produce polyunsaturated fatty acids. Together with arachidonic acid (AA), it plays an important role in the pathogenesis of Alzheimer disease. PLA2 and AA are associated with neuronal activity. Inhibition of PLA2 and AA activity could inhibit Aβinduced neurotoxicity and alleviate AD. The function of sport exercise on AD prevention and cure has been selfevident. Sport exercise inhibits PLA2 activity by inhibiting Aβ toxicity, while the mechanisms to alleviate AD learning and memory capacity still need further study. |
| Key words: Alzheimer disease Phospholipase A2 Arachidonic acid β amyloid sport training |
